"Benign" monoclonal IgE gammopathy.

Asymptomatic (benign) monoclonal gammopathy--a study of 100 patients.

The clinical and laboratory findings in 100 patients with asymptomatic (benign) monoclonal gammopathy (AMG), followed for a period of 3 to 14 years, are summarized and compared to similar findings in 60 patients with clinically overt multiple myeloma (MM). Owing to the difficulty in the early distinction between AMG and MM in patients without osteolytic bone lesions and Bence Jones proteinuria,...

Low IgE monoclonal gammopathy level in serum highlights 20-yr survival in a case of IgE multiple myeloma.

This report describes the diagnosis, follow-up, and problems measuring serum immunoglobulin E (IgE) levels in a case of IgE myeloma with 20-yr survival. Serum and urine protein electrophoresis, immunofixation, and the N Latex IgE test were used to characterize the monoclonal proteins. The diagnosis of multiple myeloma in a 56-yr-old man was based on 5.4 g/24 h of monoclonal free lambda chain in...

HIV, EBV, and monoclonal gammopathy.

In this issue of Blood, Ouedraogo et al have investigated the role of HIV and Epstein-Barr virus (EBV) replication in the persistence of monoclonal gammopathy.1 It has been known for some time that patients with HIV infection have an increased incidence of monoclonal gammopathy and plasma cell dyscrasias.2,3 The exact mechanism of monoclonal gammopathy in patients with HIV infection is unknown,...

Monoclonal gammopathy and rheumatic diseases.

It is common to find monoclonal gammopathy in the investigation workout for an unrelated disorder. There are studies relating rheumatic diseases and therapies which show an increased risk of monoclonal gammopathy. The specific mechanisms are not well understood but chronic antigen stimulation assumes an important role. Specific rheumatic diseases have consistently been associated with lymphopro...

Monoclonal gammopathy of undetermined significance.